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Vertex Pharmaceuticals Incorporated is an American biotechnology company based in Boston, Massachusetts, that focuses on developing and commercializing innovative medicines for cystic fibrosis (CF), a rare genetic disease that affects the lungs and digestive system. The company's main products are Kalydeco, Symdeko, Trikafta, and Vrondapex, which are all targeted therapies that address the underlying genetic defects in CF.